NUP107 antibody
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935106861
info@markelab.com
name
NUP107 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05919
tested applications
ELISA, WB
Description
Plays a role in the nuclear pore complex(NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nucleoporin 107kDa (NUP107) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 107 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P57740 |
| Gene ID | 57122 |
| Alias | ODG6,NUP84,NPHS11,ODG6,GAMOS7,nucleoporin 107kDa,nuclear pore complex protein Nup107 |
| Background | Antibody anti-NUP107 |
| Status | RUO |
| Note | Mol. Weight 107 kDa |
Descripción
Nucleoporin 107 (NUP107) is an integral part of the nuclear pore complex, where it plays a crucial role in the assembly and function of the pore NUP107 interacts with other nucleoporins to form the central scaffold of the pore, contributing to the selective passage of molecules, such as RNA and proteins, between the nucleus and cytoplasm NUP107 is also involved in the regulation of the cell cycle and DNA repair by ensuring proper nuclear-cytoplasmic exchange of cell cycle regulators and repair proteins Its function is critical for maintaining cellular homeostasis, as defects in nucleocytoplasmic transport can lead to diseases such as cancer and neurodegenerative disorders Dysregulation of NUP107 has been linked to increased susceptibility to genetic instability, tumor formation, and poor prognosis in several cancers Additionally, NUP107 plays a role in the maintenance of the nuclear envelope, supporting nuclear structure and stability during cell division
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