MBD2 antibody
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935106861
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name
MBD2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05034
tested applications
ELISA, WB
Description
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | methyl-CpG binding domain protein 2 (MBD2) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43-45 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UBB5 |
| Gene ID | 8932 |
| Alias | Methyl-CpG-binding domain protein 2,Demethylase (DMTase),Methyl-CpG-binding protein MBD2,MBD2 |
| Background | Antibody anti-MBD2 |
| Status | RUO |
| Note | Mol. Weight 43-45 kDa |
Descripción
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MBD2 antibody
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Ver Producto