anti- LRRC1 antibody
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935106861
info@markelab.com
name
anti- LRRC1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04852
tested applications
ELISA, IHC
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | LANO adapter protein,LAP and no PDZ protein,LANO |
| Background | Antibody anti-LRRC1 |
| Category | Primary Antibodies |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Form | liquid |
| Gene ID | 55227 |
| Host | Rabbit |
| Immunogen Target | leucine rich repeat containing 1 |
| Isotype | IgG |
| Name | anti- LRRC1 antibody |
| Note | This product is for research use only. |
| Provider | FineTest |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Reactivity | human,mouse,rat |
| Recommended Dilution | IHC: 1:20-1:200 |
| Reference | FNab04852 |
| Size 1 | 100µg |
| Status | RUO |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Tested Applications | ELISA, IHC |
| UniProt ID | Q9BTT6 |
Background en español
LRRC1 plays a vital role in cellular processes such as cytoskeletal organization and signal transduction, particularly within epithelial cells where it contributes to maintaining polarity and adherens junctions. Found predominantly in intestinal tissues, LRRC1 interacts with scaffolding proteins to stabilize E-cadherin-based complexes, which are crucial for epithelial barrier integrity. Dysfunction of LRRC1 has been associated with disorders such as inflammatory bowel disease (IBD) and colorectal cancer, as it regulates pathways like Wnt signaling and epithelial restitution after injury. Emerging studies have also indicated that LRRC1 may modulate tight junction assembly, influencing permeability and immune responses in the gut. Its role extends to being a potential marker for epithelial dysfunction, and its overexpression or loss has been implicated in epithelial-mesenchymal transition (EMT) processes linked to cancer progression. While its precise role in cancer biology remains underexplored, LRRC1's involvement in maintaining homeostasis makes it a promising candidate for therapeutic interventions targeting epithelial integrity in chronic gastrointestinal diseases and cancer.
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