Leucine Rich Repeat Containing Protein 1 (LRRC1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 1 (LRRC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234852
tested applications
ELISA, IHC
Description
LRRC1 Antibody is a Rabbit Polyclonal against LRRC1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing Protein 1 (LRRC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BTT6 |
| Gene ID | 55227 |
| OMIM | 608195 |
| Alias | LANO adapter protein,LAP and no PDZ protein,LANO |
| Background | Antibody anti-LRRC1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
LRRC1 plays a vital role in cellular processes such as cytoskeletal organization and signal transduction, particularly within epithelial cells where it contributes to maintaining polarity and adherens junctions. Found predominantly in intestinal tissues, LRRC1 interacts with scaffolding proteins to stabilize E-cadherin-based complexes, which are crucial for epithelial barrier integrity. Dysfunction of LRRC1 has been associated with disorders such as inflammatory bowel disease (IBD) and colorectal cancer, as it regulates pathways like Wnt signaling and epithelial restitution after injury. Emerging studies have also indicated that LRRC1 may modulate tight junction assembly, influencing permeability and immune responses in the gut. Its role extends to being a potential marker for epithelial dysfunction, and its overexpression or loss has been implicated in epithelial-mesenchymal transition (EMT) processes linked to cancer progression. While its precise role in cancer biology remains underexplored, LRRC1's involvement in maintaining homeostasis makes it a promising candidate for therapeutic interventions targeting epithelial integrity in chronic gastrointestinal diseases and cancer.
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