LHCGR antibody
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Name
LHCGR antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04768
Tested Applications
ELISA, WB
Description
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | luteinizing hormone/choriogonadotropin receptor (LHCGR) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 100kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22888 |
| Gene ID | 3973 |
| Alias | LHCGR,Choriogonadotropin receptor,LCGR,LGR2,LHR, lutropin-choriogonadotropic hormone receptor,LH-R,Luteinizing Hormone/Choriogonadotropin Receptor, HHG,LH/CG-R,LH/CGR,LHR,LHRHR,LSH-R,ULG5 |
| Background | Antibody anti-LHCGR |
| Status | RUO |
| Note | Mol. Weight 100 kDa |
Background
LHCGR is a G protein-coupled receptor activated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG), playing a crucial role in reproductive function. It is expressed in ovarian theca and granulosa cells in females and Leydig cells in males. In females, LHCGR regulates ovulation, corpus luteum formation, and progesterone production during the menstrual cycle and pregnancy. In males, LHCGR stimulates testosterone synthesis in Leydig cells, which supports spermatogenesis. LHCGR signaling activates adenylyl cyclase through Gs proteins, increasing cAMP levels and activating protein kinase A (PKA), which regulates steroidogenesis and cell proliferation. Mutations in LHCGR are linked to disorders such as precocious puberty, infertility, and hypogonadism. Overexpression of LHCGR has been observed in hormone-dependent cancers, including ovarian and testicular tumors, where it drives abnormal growth and survival. Therapeutically, LH/hCG analogs are used to treat infertility, while LHCGR antagonists are being explored for hormone-related cancers. LHCGR is vital for maintaining reproductive health and steroid hormone production.
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