Human LHCGR(Lutropin-choriogonadotropic hormone receptor) ELISA Kit
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935106861
info@markelab.com
name
Human LHCGR(Lutropin-choriogonadotropic hormone receptor) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH1592
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Reactivity | human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Size 1 | 96T |
| Sample Type | Serum,Plasma,Tissue homogenates,Other biological fluids |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 6 months |
| UniProt ID | P22888 |
| Alias | LHCGR,Choriogonadotropin receptor,LCGR,LGR2,LHR, lutropin-choriogonadotropic hormone receptor,LH-R,Luteinizing Hormone/Choriogonadotropin Receptor, HHG,LH/CG-R,LH/CGR,LHR,LHRHR,LSH-R,ULG5 |
| Background | Elisa Kits LHCGR |
| Status | RUO |
LHCGR is a G protein-coupled receptor activated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG), playing a crucial role in reproductive function. It is expressed in ovarian theca and granulosa cells in females and Leydig cells in males. In females, LHCGR regulates ovulation, corpus luteum formation, and progesterone production during the menstrual cycle and pregnancy. In males, LHCGR stimulates testosterone synthesis in Leydig cells, which supports spermatogenesis. LHCGR signaling activates adenylyl cyclase through Gs proteins, increasing cAMP levels and activating protein kinase A (PKA), which regulates steroidogenesis and cell proliferation. Mutations in LHCGR are linked to disorders such as precocious puberty, infertility, and hypogonadism. Overexpression of LHCGR has been observed in hormone-dependent cancers, including ovarian and testicular tumors, where it drives abnormal growth and survival. Therapeutically, LH/hCG analogs are used to treat infertility, while LHCGR antagonists are being explored for hormone-related cancers. LHCGR is vital for maintaining reproductive health and steroid hormone production.
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