anti- LGR6 antibody

Descripción

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

leucine-rich repeat-containing G protein-coupled receptor 6

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, IHC, WB, FC

observerd MW

104 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:1000; IHC: 1:20-1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

LGR6

alias

LGR6,VTS20631,leucine-rich repeat-containing G protein-coupled receptor 6,leucine-rich repeat containing G protein-coupled receptor 6

uniprot id

https://www.uniprot.org/uniprotkb/Q9HBX8

gene id

https://www.ncbi.nlm.nih.gov/gene/59352

note

This product is for research use only.

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