IL31 antibody
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935106861
info@markelab.com
name
IL31 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04269
tested applications
ELISA, IHC
Description
Interleukin-31(IL-31) is a newly discovered four-helix bundle cytokine and expressed by several types of cells under both normal and disease state, such as activated CD4+T cells, mast cells, monocytes, macrophages, immature and mature monocyte-derived dendritic cells and so on. IL-31 signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha(IL31Rα) and the oncostatin
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 31 (IL31) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6EBC2 |
| Gene ID | 386653 |
| Alias | IL-31 |
| Background | Antibody anti-IL31 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Interleukin 31 (IL31) is a cytokine belonging to the IL-6 cytokine family that plays a central role in the regulation of immune responses and is heavily implicated in inflammatory processes, particularly in chronic pruritic (itching) skin disorders. IL-31 is primarily produced by activated T helper 2 (Th2) cells, a subset of T cells involved in allergic responses and the regulation of immune responses to extracellular pathogens. IL-31 was discovered as a cytokine that can link the immune system with the nervous system, particularly in the skin, where it triggers pruritus and inflammatory responses. The IL-31 receptor is widely expressed, being found on keratinocytes, fibroblasts, epithelial cells, and immune cells, which suggests its involvement in skin and tissue homeostasis
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