HCAR1 antibody
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935106861
info@markelab.com
name
HCAR1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03610
tested applications
ELISA, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G protein-coupled receptor 81 (HCAR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BXC0 |
| Alias | HCAR1,FKSG80,LACR1,lactate receptor 1,T-cell activation G protein-coupled receptor,G protein-coupled receptor 104,G protein-coupled receptor 81,Gpr81,FKSG80, GPR104, GPR81, HCA1,TA-GPCR, TAGPCR |
| Background | Antibody anti-HCAR1 |
| Status | RUO |
| Note | This product is for research use only. |
HCAR1, also known as GPR81, is a G protein-coupled receptor that responds to lactate, a key metabolite produced during glycolysis. HCAR1 is primarily expressed in adipose tissue, skeletal muscle, and the central nervous system, where it plays a critical role in energy metabolism. Activation of HCAR1 inhibits adenylate cyclase via Gi/o proteins, reducing intracellular cAMP levels and suppressing lipolysis in adipocytes. This action helps conserve energy during periods of high lactate production, such as intense exercise or hypoxia. HCAR1 also regulates metabolic signaling in the liver and brain, where lactate serves as both an energy substrate and signaling molecule. Dysregulation of HCAR1 signaling is associated with metabolic disorders, including obesity, insulin resistance, and type 2 diabetes. Recent studies suggest HCAR1’s involvement in neuroprotection, where lactate signaling may support neuronal survival during metabolic stress. HCAR1 is a promising therapeutic target for metabolic diseases, neuroprotection, and conditions involving excessive lipolysis.
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