anti- GPR37/Pael-R antibody

Product specifications

Primary Antibodies

G protein-coupled receptor 37(endothelin receptor type B-like)

Rabbit

human,mouse,rat

WB: 1:500-1:2000

polyclonal

Unconjugated

IgG

50-55kd

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA, WB

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

O15354

GPR37,EDNRBL,EDNRLB,PAELR,G-protein coupled receptor CNS1,parkin-associated endothelin B-like receptor,Endothelin B receptor-like protein 1,hET(B)R-LP

Antibody anti-GPR37

RUO

This product is for research use only.

GPR37, also known as the parkin receptor, is a G protein-coupled receptor expressed primarily in the brain, particularly in dopaminergic neurons. GPR37 plays an important role in regulating neuronal signaling, synaptic plasticity, and neuroinflammation. It is activated by its endogenous ligand, which remains largely unidentified, and couples to Gi proteins, leading to the inhibition of adenylate cyclase and modulation of other intracellular signaling pathways. GPR37 is involved in the pathophysiology of Parkinson's disease, as it is associated with the parkin gene, which is implicated in the degeneration of dopaminergic neurons. Mutations in the GPR37 gene have been linked to various neurodegenerative diseases, making this receptor an interesting target for therapeutic research. The receptor's potential as a modulator of neuroinflammation and neuronal survival is being explored for new treatments aimed at neurodegenerative diseases such as Parkinson’s.

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