GABARAPL1-Specific antibody
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935106861
info@markelab.com
name
GABARAPL1-Specific antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03276
tested applications
ELISA, WB, IHC, IP, IF
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GABA(A) receptor-associated protein like 1 (GABARAPL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 16 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H0R8 |
| Alias | APG8-LIKE,APG8L,ATG8,ATG8B,ATG8L,GEC1 |
| Background | Antibody anti-GABARAPL1 |
| Status | RUO |
| Note | Mol. Weight 16 kDa |
GABARAPL1 is a member of the GABARAP (GABA-A receptor-associated protein) family, which plays a key role in intracellular trafficking, autophagy, and receptor regulation. It facilitates the transport and membrane localization of GABA-A receptors, contributing to inhibitory neurotransmission in the central nervous system. Beyond its role in neurotransmitter signaling, GABARAPL1 is a critical component of the autophagy machinery, interacting with ATG proteins to regulate autophagosome formation and cargo sequestration. It is involved in cellular homeostasis, protein degradation, and stress responses. Dysregulation of GABARAPL1 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where impaired autophagy disrupts protein clearance and neuronal survival. GABARAPL1 is also implicated in cancer, where altered expression influences tumor progression, survival, and chemoresistance through autophagy modulation. Its dual role in receptor trafficking and autophagy highlights GABARAPL1 as a critical regulator of cellular and neuronal function, making it a potential therapeutic target in neurodegeneration and cancer.
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