anti- E2F7 antibody
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Description
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E2F transcription factor 7 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 95 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96AV8 |
| Gene ID | 144455 |
| Alias | E2F-7 |
| Background | Antibody anti-E2F7 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
E2F7 is an atypical E2F transcription factor that functions as a repressor of E2F target genes, particularly those involved in DNA replication and cell cycle progression. Unlike classical E2Fs, E2F7 contains two DNA-binding domains but lacks a transactivation domain, enabling it to directly bind and repress target promoters without the involvement of RB proteins. E2F7 is upregulated during the G2/M phase and acts as a negative feedback regulator to suppress E2F-driven proliferation. It plays a key role in cellular stress responses, where it regulates genes involved in DNA damage repair, such as p53 target genes, to maintain genomic stability. Dysregulation of E2F7 contributes to tumorigenesis by disrupting cell cycle checkpoints and DNA damage responses. Knockout studies show increased sensitivity to DNA damage, defective cell cycle arrest, and aberrant proliferation, underscoring E2F7’s role in genomic maintenance, stress response, and tumor suppression.
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