CSE1L antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates(cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CSE1 chromosome segregation 1-like(yeast) (CSE1L) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 100-110 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P55060 |
| Gene ID | 1434 |
| Alias | Exportin-2 (Exp2),Cellular apoptosis susceptibility protein,Chromosome segregation 1-like protein,Importin-alpha re-exporter,CSE1L,CAS,XPO2 |
| Background | Antibody anti-CSE1L |
| Status | RUO |
| Note | Mol. Weight 100-110 kDa |
Descripción
Related Products
CSE1L antibody
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates(cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.
Ver Producto
Chromosome Segregation 1 Like (CSE1L) Antibody
Cse1 Chromosome Segregation 1-Like (Yeast) Antibody is a Rabbit Polyclonal antibody against Cse1 Chromosome Segregation 1-Like (Yeast).
Ver ProductoChromosome Segregation 1 Like (CSE1L) Antibody
CSE1L Antibody is a Rabbit Polyclonal antibody against CSE1L.
Ver Producto