CLK2 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich(SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor(F3) pre-mRNA in endothelial cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CDC-like kinase 2 (CLK2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | 0 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P49760 |
| Gene ID | 1196 |
| Alias | Dual specificity protein kinase CLK2,CDC-like kinase 2,CLK2 |
| Background | Antibody anti-CLK2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Related Products
CLK2 antibody
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich(SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor(F3) pre-mRNA in endothelial cells.
Ver Producto
Dual Specificity Protein Kinase CLK2 (CLK2) Antibody
CLK2 Antibody is a Rabbit Polyclonal Antibody against CLK2.
Ver Producto
Dual Specificity Protein Kinase CLK2 (CLK2) Antibody
Rabbit polyclonal antibody against CLK2 protein. Immunogen region is N-terminal.
Ver Producto