ITGAM antibody

Este producto es parte de ITGAM - integrin subunit alpha M
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935106861
info@markelab.com
name
ITGAM antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01410
tested applications
ELISA, WB, IHC

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
integrin, alpha M(complement component 3 receptor 3 subunit) (ITGAM)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:50-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
180 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P11215
Gene ID
3684
Alias
CR3A,MO1A,CD11B,MAC-1,MAC1A,SLEB6,CD11 antigen-like family member B,CR-3 alpha chain,Cell surface glycoprotein MAC-1 subunit alpha,Leukocyte adhesion receptor MO1,Neutrophil adherence receptor
Background
Antibody anti-ITGAM
Status
RUO
Note
Mol. Weight 180 kDa

Integrin Subunit Alpha M (ITGAM), also known as CD11b, is a transmembrane glycoprotein expressed predominantly on the surface of monocytes, macrophages, granulocytes, and some dendritic cells. ITGAM forms a heterodimer with integrin beta-2 (ITGB2) to create the Mac-1 complex, which is crucial in mediating adhesion and migration of leukocytes during inflammatory and immune responses. The protein plays a pivotal role in immune surveillance and host defense by facilitating phagocytosis, complement receptor activity, and migration across endothelial barriers. Additionally, ITGAM is involved in the recognition and clearance of pathogens and apoptotic cells. Aberrations in ITGAM expression or mutations have been linked to systemic lupus erythematosus (SLE) and other autoimmune disorders. It is also a key player in immune evasion mechanisms employed by certain pathogens.

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