BAX antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
BAX antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00810
Tested Applications
ELISA, WB, IHC, IP, FC
Description
BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | BCL2-associated X protein (BAX) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Rabbit, Sheep |
| Recommended Dilution | WB: 1:1000-1:10000; IP: 1:1000-1:10000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 21 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q07812 |
| Gene ID | 581 |
| Alias | BAX,BCL2L4,BCL2 associated X protein,Bcl-2-like protein 4,Bcl2-L-4 |
| Background | Antibody anti-BAX |
| Status | RUO |
| Note | Mol. Weight 21 kDa |
Background
BCL2 associated X, apoptosis regulator (BAX) is a pro-apoptotic protein that plays a critical role in mitochondrial-mediated apoptosis, a key process in regulating cell death BAX is activated in response to various stress signals, including DNA damage and oxidative stress, and it translocates to the mitochondria, where it promotes the release of cytochrome c, leading to the activation of caspases and cell death BAX functions as a counterpart to anti-apoptotic proteins like BCL2, which inhibit apoptosis BAX's activity is tightly regulated, as excessive activation can lead to uncontrolled cell death and tissue damage Its dysregulation has been implicated in several diseases, including cancer, where reduced BAX activity allows tumor cells to evade apoptosis, contributing to tumor progression and resistance to therapy BAX also has a role in regulating immune responses, particularly in T-cell development and survival, making it crucial for immune system homeostasis Additionally, BAX is involved in neurodegenerative diseases, where excessive cell death in neurons leads to conditions like Alzheimer's and Parkinson's
Productos relacionados
Bcl2 Associated X Protein (BAX) Antibody
BAX Antibody is a Rabbit Polyclonal antibody against BAX. The protein encoded by this gene belongs to the BCL2 protein f…
Ver producto
Bcl2 Associated X Protein (BAX) Antibody
BAX Antibody is a Rabbit Polyclonal Antibody against BAX.…
Ver producto
Bcl2 Associated X Protein (BAX) Antibody
Bcl2 Associated X Protein (BAX) Antibody is a Rabbit Polyclonal antibody for the detection of BAX.…
Ver producto