BAX antibody

Este producto es parte de BAX - Apoptosis regulator BAX
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935106861
info@markelab.com
name
BAX antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00809
tested applications
ELISA, WB, IHC, IF

Description

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
BCL2-associated X protein (BAX)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
21 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
UniProt ID
Q07812
Gene ID
581
Alias
BAX,BCL2L4,BCL2 associated X protein,Bcl-2-like protein 4,Bcl2-L-4
Background
Antibody anti-BAX
Status
RUO
Note
Mol. Weight 21 kDa

Descripción

BCL2 associated X, apoptosis regulator (BAX) is a pro-apoptotic protein that plays a critical role in mitochondrial-mediated apoptosis, a key process in regulating cell death BAX is activated in response to various stress signals, including DNA damage and oxidative stress, and it translocates to the mitochondria, where it promotes the release of cytochrome c, leading to the activation of caspases and cell death BAX functions as a counterpart to anti-apoptotic proteins like BCL2, which inhibit apoptosis BAX's activity is tightly regulated, as excessive activation can lead to uncontrolled cell death and tissue damage Its dysregulation has been implicated in several diseases, including cancer, where reduced BAX activity allows tumor cells to evade apoptosis, contributing to tumor progression and resistance to therapy BAX also has a role in regulating immune responses, particularly in T-cell development and survival, making it crucial for immune system homeostasis Additionally, BAX is involved in neurodegenerative diseases, where excessive cell death in neurons leads to conditions like Alzheimer's and Parkinson's

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BAX antibody

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

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BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

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