ATP2C1 antibody
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Description
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 101 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P98194 |
| Gene ID | 27032 |
| Alias | Calcium-transporting ATPase type 2C member 1 (ATPase 2C1),ATP-dependent Ca(2+) pump PMR1,Ca(2+)/Mn(2+)-ATPase 2C1,Secretory pathway Ca(2+)-transporting ATPase type 1 (SPCA1),ATP2C1,KIAA1347,PMR1L |
| Background | Antibody anti-ATP2C1 |
| Status | RUO |
| Note | Mol. Weight 101 kDa |
Descripción
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ATP2C1 antibody
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
ATP2C1 Antibody is a Rabbit Polyclonal Antibody against ATP2C1.
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Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco (endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
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