anti- Apolipoprotein A II antibody

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Precio
Precio a consultar
Antibody anti-APOA2
proveedor
FineTestreference
FNab00507Tested Applications
ELISA, WB, IHCreactivity
humanstatus
RUOclonality
polyclonalDescripción
The predicted MW of ApoA2 is 11 kDa, while the mature form is smaller (7-10 kDa) since the signal peptide was cleaved. In humans, most of circulating apoA2 exist as dimer.
Background
APOA2 is the second most abundant protein in HDL particles and is involved in stabilizing HDL structure and influencing cholesterol metabolism. It plays a role in modulating HDL remodeling, impacting the balance between cholesterol efflux and lipid delivery. APOA2 has a controversial role in cardiovascular health, with studies showing both pro-atherogenic and anti-atherogenic effects depending on genetic variants and lipid context. Elevated APOA2 levels have been linked to obesity, insulin resistance, and metabolic syndrome, while deficiencies can impair HDL stability and function. APOA2 interacts with enzymes like hepatic lipase and proteins such as CETP (cholesteryl ester transfer protein), which regulate lipid exchange and metabolism. Its dual role in lipid homeostasis and metabolic health highlights its significance in cardiovascular disease and metabolic disorders.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human
immunogen target
apolipoprotein A-II
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IHC
observerd MW
15 kDa,11 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
APOA2
alias
APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2,APO A2,APO-A2,Apolipoprotein A-II
uniprot id
note
This product is for research use only.
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
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