APOA2 antibody
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935106861
info@markelab.com
name
APOA2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00507
tested applications
ELISA, WB, IHC
Description
The predicted MW of ApoA2 is 11 kDa, while the mature form is smaller (7-10 kDa) since the signal peptide was cleaved. In humans, most of circulating apoA2 exist as dimer.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | apolipoprotein A-II (APOA2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 15 kDa,11 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P02652 |
| Gene ID | 336 |
| Alias | APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2,APO A2,APO-A2,Apolipoprotein A-II |
| Background | Antibody anti-APOA2 |
| Status | RUO |
| Note | Mol. Weight 15 kDa, 11 kDa |
Descripción
APOA2 is the second most abundant protein in HDL particles and is involved in stabilizing HDL structure and influencing cholesterol metabolism. It plays a role in modulating HDL remodeling, impacting the balance between cholesterol efflux and lipid delivery. APOA2 has a controversial role in cardiovascular health, with studies showing both pro-atherogenic and anti-atherogenic effects depending on genetic variants and lipid context. Elevated APOA2 levels have been linked to obesity, insulin resistance, and metabolic syndrome, while deficiencies can impair HDL stability and function. APOA2 interacts with enzymes like hepatic lipase and proteins such as CETP (cholesteryl ester transfer protein), which regulate lipid exchange and metabolism. Its dual role in lipid homeostasis and metabolic health highlights its significance in cardiovascular disease and metabolic disorders.
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APOA2 antibody
The predicted MW of ApoA2 is 11 kDa, while the mature form is smaller (7-10 kDa) since the signal peptide was cleaved. In humans, most of circulating apoA2 exist as dimer.
Ver Producto