ANO3 antibody
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935106861
info@markelab.com
name
ANO3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00443
tested applications
ELISA, WB, IP
Description
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity(By similarity). Does not exhibit calcium-activated chloride channel(CaCC) activity.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | anoctamin 3 (ANO3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 115 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BYT9 |
| Gene ID | 63982 |
| Alias | ANO3,C11orf25,TMEM16C |
| Background | Antibody anti-ANO3 |
| Status | RUO |
| Note | Mol. Weight 115 kDa |
Descripción
ANO3, also known as TMEM16C, is a member of the anoctamin family with roles in neuronal signaling and ion channel regulation. ANO3 is expressed in specific regions of the nervous system, including motor neurons and sensory neurons, where it may regulate calcium signaling and ion fluxes critical for neuronal function. Mutations in ANO3 have been linked to dystonia, a neurological movement disorder characterized by involuntary muscle contractions, abnormal postures, and impaired motor control. ANO3’s role in modulating neuronal excitability and neurotransmitter release highlights its importance in maintaining normal motor neuron function. Dysregulation or mutations disrupt calcium signaling and neuronal communication, leading to motor dysfunction and neurodegenerative diseases.
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