Anoctamin 3 (ANO3) Antibody
377€ (100 µg)
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Name
Anoctamin 3 (ANO3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230443
Tested Applications
ELISA, WB, IP
Description
ANO3 Antibody is a Rabbit Polyclonal against ANO3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Anoctamin 3 (ANO3) Immunogen: anoctamin 3 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/5000, IP: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 115 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BYT9 |
| Gene ID | 63982 |
| OMIM | 610110 |
| Alias | ANO3,C11orf25,TMEM16C |
| Background | Antibody anti-ANO3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANO3, also known as TMEM16C, is a member of the anoctamin family with roles in neuronal signaling and ion channel regulation. ANO3 is expressed in specific regions of the nervous system, including motor neurons and sensory neurons, where it may regulate calcium signaling and ion fluxes critical for neuronal function. Mutations in ANO3 have been linked to dystonia, a neurological movement disorder characterized by involuntary muscle contractions, abnormal postures, and impaired motor control. ANO3’s role in modulating neuronal excitability and neurotransmitter release highlights its importance in maintaining normal motor neuron function. Dysregulation or mutations disrupt calcium signaling and neuronal communication, leading to motor dysfunction and neurodegenerative diseases.
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