ANO10 antibody
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935106861
info@markelab.com
name
ANO10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00441
tested applications
ELISA, WB, IP, IHC
Description
Does not exhibit calcium-activated chloride channel(CaCC) activity. Can inhibit the activity of ANO1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | anoctamin 10 (ANO10) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 76 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NW15 |
| Gene ID | 55129 |
| Alias | ANO10,TMEM16K |
| Background | Antibody anti-ANO10 |
| Status | RUO |
| Note | Mol. Weight 76 kDa |
Descripción
ANO10 is a member of the anoctamin family but is distinct from other family members in its function and expression patterns. ANO10 has been implicated in cellular processes such as lipid metabolism, membrane trafficking, and calcium signaling. It is primarily expressed in the nervous system and has been linked to neurodegenerative disorders. Mutations in the ANO10 gene are associated with spinocerebellar ataxia type 10 (SCA10), a progressive neurodegenerative disease characterized by gait imbalance, ataxia, and cerebellar dysfunction. ANO10's role in maintaining neuronal integrity and its involvement in calcium-regulated signaling highlight its importance in the normal function of the central nervous system. Dysregulation or mutation can lead to impaired neuronal signaling and degeneration.
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