ANKRD13A antibody
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935106861
info@markelab.com
name
ANKRD13A antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00406
tested applications
ELISA, WB, IF
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat domain 13A (ANKRD13A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:1000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 68 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IZ07 |
| Gene ID | 88455 |
| Alias | ANKRD13A,ANKRD13,KE03 |
| Background | Antibody anti-ANKRD13A |
| Status | RUO |
| Note | Mol. Weight 68 kDa |
Descripción
ANKRD13A is a member of the ankyrin repeat domain-containing protein family, which is characterized by its ankyrin repeats that mediate protein-protein interactions. ANKRD13A is involved in regulating protein trafficking and ubiquitination, particularly through interactions with proteins targeted for degradation or recycling. It localizes to the endosomal membrane, where it plays a role in controlling the fate of membrane proteins such as receptors and ion channels. ANKRD13A has been shown to interact with ubiquitin-binding domains, suggesting its participation in protein quality control and cellular homeostasis. Dysregulation of ANKRD13A may contribute to altered protein turnover, leading to diseases such as cancer and neurodegenerative disorders, where disrupted trafficking and degradation pathways play critical roles. Its role in protein regulation highlights its importance in maintaining cellular function and integrity.
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