anti- ANKRD13A antibody
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info@markelab.com
Precio
Precio a consultar
Antibody anti-ANKRD13A
proveedor
FineTestreference
FNab00406Tested Applications
ELISA, WB, IFreactivity
humanstatus
RUOclonality
polyclonalDescripción
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Background
ANKRD13A is a member of the ankyrin repeat domain-containing protein family, which is characterized by its ankyrin repeats that mediate protein-protein interactions. ANKRD13A is involved in regulating protein trafficking and ubiquitination, particularly through interactions with proteins targeted for degradation or recycling. It localizes to the endosomal membrane, where it plays a role in controlling the fate of membrane proteins such as receptors and ion channels. ANKRD13A has been shown to interact with ubiquitin-binding domains, suggesting its participation in protein quality control and cellular homeostasis. Dysregulation of ANKRD13A may contribute to altered protein turnover, leading to diseases such as cancer and neurodegenerative disorders, where disrupted trafficking and degradation pathways play critical roles. Its role in protein regulation highlights its importance in maintaining cellular function and integrity.
Características del producto
category
Primary Antibodies
clonality
polyclonal
reactivity
human
immunogen target
ankyrin repeat domain 13A
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
liquid
tested applications
ELISA, WB, IF
observerd MW
68 kDa
purity
≥95% as determined by SDS-PAGE
purification
Immunogen affinity purified
recommended dilution
WB: 1:200-1:1000; IF: 1:10-1:100
size 1
100µg
storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
or code
ANKRD13A
alias
ANKRD13A,ANKRD13,KE03
uniprot id
note
This product is for research use only.
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