anti- ANKRD13A antibody

Este producto es parte de ANKRD - Ankyrin repeat domain
anti- ANKRD13A antibody

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935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-ANKRD13A

proveedor

FineTest

reference

FNab00406

Tested Applications

ELISA, WB, IF

reactivity

human

status

RUO

clonality

polyclonal

Descripción

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.


Background

ANKRD13A is a member of the ankyrin repeat domain-containing protein family, which is characterized by its ankyrin repeats that mediate protein-protein interactions. ANKRD13A is involved in regulating protein trafficking and ubiquitination, particularly through interactions with proteins targeted for degradation or recycling. It localizes to the endosomal membrane, where it plays a role in controlling the fate of membrane proteins such as receptors and ion channels. ANKRD13A has been shown to interact with ubiquitin-binding domains, suggesting its participation in protein quality control and cellular homeostasis. Dysregulation of ANKRD13A may contribute to altered protein turnover, leading to diseases such as cancer and neurodegenerative disorders, where disrupted trafficking and degradation pathways play critical roles. Its role in protein regulation highlights its importance in maintaining cellular function and integrity.

Características del producto

category

Primary Antibodies


clonality

polyclonal


reactivity

human


immunogen target

ankyrin repeat domain 13A


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

liquid


tested applications

ELISA, WB, IF


observerd MW

68 kDa


purity

≥95% as determined by SDS-PAGE


purification

Immunogen affinity purified


recommended dilution

WB: 1:200-1:1000; IF: 1:10-1:100


size 1

100µg


storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)


or code

ANKRD13A


alias

ANKRD13A,ANKRD13,KE03


note

This product is for research use only.


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