AMZ2 antibody
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935106861
info@markelab.com
name
AMZ2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00386
tested applications
ELISA, WB, IHC
Description
Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | archaelysin family metallopeptidase 2 (AMZ2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 41 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86W34 |
| Gene ID | 51321 |
| Alias | AMZ2 |
| Background | Antibody anti-AMZ2 |
| Status | RUO |
| Note | Mol. Weight 41 kDa |
Descripción
AMZ2, like AMZ1, is a zinc-dependent metallopeptidase that functions in the regulation of protein degradation and extracellular matrix remodeling. AMZ2 is widely expressed in tissues, including those involved in immune responses and connective tissue maintenance. AMZ2 has been shown to play a role in proteolytic processes that modulate cellular signaling pathways, tissue repair, and organ development. Its enzymatic activity depends on zinc ions, which are essential for stabilizing the active site and facilitating substrate cleavage. AMZ2 is involved in regulating inflammatory processes by processing bioactive peptides and matrix proteins, contributing to tissue remodeling during immune responses and injury repair. Dysregulation of AMZ2 has been associated with chronic inflammation, cancer progression, and neurodegenerative diseases, where altered proteolytic activity can disrupt tissue integrity and cellular signaling. AMZ2 is emerging as a potential target for therapeutic interventions aimed at modulating protease activity in pathological conditions.
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