AMOTL1 antibody
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935106861
info@markelab.com
name
AMOTL1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00369
tested applications
ELISA, WB
Description
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | angiomotin like 1 (AMOTL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 107 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IY63 |
| Gene ID | 154810 |
| Alias | JEAP |
| Background | Antibody anti-AMOTL1 |
| Status | RUO |
| Note | Mol. Weight 107 kDa |
Descripción
Angiomotin Like 1 (AMOTL1) is a member of the angiomotin protein family, which is involved in regulating endothelial cell migration, polarity, and vascular stability. AMOTL1 plays a crucial role in maintaining endothelial barrier function and modulating angiogenesis by interacting with tight junction proteins and signaling pathways. It is known to participate in the regulation of the Hippo signaling pathway, where it influences cell proliferation and organ size by interacting with transcriptional regulators such as YAP and TAZ. AMOTL1 is also implicated in tumor progression, as it can modulate cell migration, adhesion, and invasion in cancer cells. Dysregulation of AMOTL1 has been associated with pathological angiogenesis, cancer metastasis, and inflammatory diseases. Its function in maintaining vascular integrity and its interaction with key signaling pathways make AMOTL1 a promising target for therapeutic interventions in vascular disorders and oncology.
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