AMIGO3 antibody
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935106861
info@markelab.com
name
AMIGO3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00361
tested applications
ELISA, WB
Description
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adhesion molecule with Ig-like domain 3 (AMIGO3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86WK7 |
| Gene ID | 386724 |
| Alias | AMIGO3,ALI3,Alivin-3 |
| Background | Antibody anti-AMIGO3 |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
AMIGO3 is a member of the AMIGO family that primarily functions in cell adhesion, neuronal development, and cell survival signaling. It is expressed in the central nervous system, where it regulates axon guidance and myelination during neural development. AMIGO3 interacts with other adhesion molecules and extracellular ligands to modulate axon extension and fasciculation, contributing to the formation of functional neural networks. Beyond its role in neural development, AMIGO3 has been implicated in promoting neuronal apoptosis in response to injury or stress, particularly in neuroinflammatory and neurodegenerative conditions. It has also been linked to tumor progression, where it enhances cancer cell survival, migration, and invasion. AMIGO3 is involved in activating signaling pathways such as NF-κB and PI3K/AKT, which support cell survival and inflammatory responses. Its involvement in both neural apoptosis and cancer progression highlights AMIGO3 as a critical player in cellular signaling pathways related to survival and disease.
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