anti- ALX3 antibody
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935106861
info@markelab.com
name
anti- ALX3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00353
tested applications
ELISA, WB
Description
Transcriptional regulator with a possible role in patterning of mesoderm during development.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALX homeobox 3 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95076 |
| Gene ID | 257 |
| Alias | FND,FND1 |
| Background | Antibody anti-ALX3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ALX3 is a transcription factor belonging to the homeobox gene family, which regulates developmental processes, including craniofacial development, limb formation, and neural crest cell differentiation. ALX3 is expressed in facial mesenchymal tissues during embryogenesis, where it controls genes necessary for midline and upper facial development. Mutations or dysregulation of ALX3 are linked to frontonasal dysplasia, characterized by cleft lip/palate, hypertelorism, and nasal malformations. ALX3 has been shown to interact with other transcription factors and signaling pathways to regulate the proliferation and migration of mesenchymal cells. Emerging studies suggest ALX3 may act as a tumor suppressor in certain cancers, as its expression has been shown to inhibit cell proliferation and epithelial-mesenchymal transition (EMT). Its role in regulating gene expression during development and disease highlights ALX3 as a potential target for understanding congenital malformations and tumorigenesis.
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