ALX Homeobox 3 (ALX3) Antibody
357.5€ (100 µg)
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name
ALX Homeobox 3 (ALX3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037640
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ALX3 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALX Homeobox 3 (ALX3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_006483.2 |
| Alias | FND,FND1 |
| Background | Antibody anti-ALX3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ALX3 is a transcription factor belonging to the homeobox gene family, which regulates developmental processes, including craniofacial development, limb formation, and neural crest cell differentiation. ALX3 is expressed in facial mesenchymal tissues during embryogenesis, where it controls genes necessary for midline and upper facial development. Mutations or dysregulation of ALX3 are linked to frontonasal dysplasia, characterized by cleft lip/palate, hypertelorism, and nasal malformations. ALX3 has been shown to interact with other transcription factors and signaling pathways to regulate the proliferation and migration of mesenchymal cells. Emerging studies suggest ALX3 may act as a tumor suppressor in certain cancers, as its expression has been shown to inhibit cell proliferation and epithelial-mesenchymal transition (EMT). Its role in regulating gene expression during development and disease highlights ALX3 as a potential target for understanding congenital malformations and tumorigenesis.
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