ALX Homeobox 3 (ALX3) Antibody
52€ (10 µg)
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935106861
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name
ALX Homeobox 3 (ALX3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013334
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against ALX3 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALX Homeobox 3 (ALX3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95076 |
| Alias | FND,FND1 |
| Background | Antibody anti-ALX3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ALX3 is a transcription factor belonging to the homeobox gene family, which regulates developmental processes, including craniofacial development, limb formation, and neural crest cell differentiation. ALX3 is expressed in facial mesenchymal tissues during embryogenesis, where it controls genes necessary for midline and upper facial development. Mutations or dysregulation of ALX3 are linked to frontonasal dysplasia, characterized by cleft lip/palate, hypertelorism, and nasal malformations. ALX3 has been shown to interact with other transcription factors and signaling pathways to regulate the proliferation and migration of mesenchymal cells. Emerging studies suggest ALX3 may act as a tumor suppressor in certain cancers, as its expression has been shown to inhibit cell proliferation and epithelial-mesenchymal transition (EMT). Its role in regulating gene expression during development and disease highlights ALX3 as a potential target for understanding congenital malformations and tumorigenesis.
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