anti- ALPK1 antibody
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935106861
info@markelab.com
name
anti- ALPK1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00346
tested applications
ELISA, WB, IHC
Description
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alpha-kinase 1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 139 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96QP1 |
| Gene ID | 80216 |
| Alias | Lymphocyte alpha-protein kinase |
| Background | Antibody anti-ALPK1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Alpha-Protein Kinase 1 (ALPK1) is a serine/threonine kinase belonging to the alpha-protein kinase family, characterized by its atypical catalytic domain structure. ALPK1 plays a role in various cellular processes, including protein trafficking, inflammation, and innate immune signaling. It is involved in the Golgi-to-endoplasmic reticulum (ER) transport pathway and has been implicated in the regulation of vesicle trafficking. ALPK1 is also recognized as a critical mediator of inflammatory responses, where it activates signaling pathways such as NF-kB and MAPK in response to pathogenic stimuli. Genetic mutations or dysregulation of ALPK1 have been associated with inflammatory diseases, including gouty arthritis and familial autoinflammatory conditions such as ALPK1-associated autoinflammatory syndrome. In addition, emerging evidence suggests that ALPK1 may contribute to tumorigenesis through its role in cellular signaling and inflammation. Therapeutic strategies targeting ALPK1 are being explored to modulate inflammation and immune responses, with potential implications for treating inflammatory and autoimmune diseases.
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