Alpha-Protein Kinase 1 (ALPK1) Antibody
357.5€ (100 µg)
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935106861
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name
Alpha-Protein Kinase 1 (ALPK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037399
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ALPK1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Alpha-Protein Kinase 1 (ALPK1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_001102406.1 |
| Alias | Lymphocyte alpha-protein kinase |
| Background | Antibody anti-ALPK1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Alpha-Protein Kinase 1 (ALPK1) is a serine/threonine kinase belonging to the alpha-protein kinase family, characterized by its atypical catalytic domain structure. ALPK1 plays a role in various cellular processes, including protein trafficking, inflammation, and innate immune signaling. It is involved in the Golgi-to-endoplasmic reticulum (ER) transport pathway and has been implicated in the regulation of vesicle trafficking. ALPK1 is also recognized as a critical mediator of inflammatory responses, where it activates signaling pathways such as NF-kB and MAPK in response to pathogenic stimuli. Genetic mutations or dysregulation of ALPK1 have been associated with inflammatory diseases, including gouty arthritis and familial autoinflammatory conditions such as ALPK1-associated autoinflammatory syndrome. In addition, emerging evidence suggests that ALPK1 may contribute to tumorigenesis through its role in cellular signaling and inflammation. Therapeutic strategies targeting ALPK1 are being explored to modulate inflammation and immune responses, with potential implications for treating inflammatory and autoimmune diseases.
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