anti- ALDH8A1 antibody
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935106861
info@markelab.com
name
anti- ALDH8A1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00300
tested applications
ELISA, WB, IHC,IF
Description
Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal(in vitro). Has a preference for NAD, but shows considerable activity with NADP(in vitro).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 8 family, member A1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 53 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC,IF |
| Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H2A2 |
| Gene ID | 64577 |
| Alias | ALDH8A1,ALDH12 |
| Background | Antibody anti-ALDH8A1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ALDH8A1 is a cytosolic enzyme primarily involved in the metabolism of retinaldehyde to retinoic acid, a key signaling molecule that regulates cell differentiation, growth, and tissue homeostasis. ALDH8A1 is expressed in metabolic tissues, including the liver, kidneys, and retina, where it supports retinoid metabolism and vitamin A homeostasis. Its role in converting retinaldehyde to retinoic acid makes ALDH8A1 critical for maintaining vision, embryonic development, and immune responses. Dysregulation of ALDH8A1 has been implicated in retinal diseases, such as age-related macular degeneration (AMD), and developmental abnormalities caused by retinoic acid deficiency. ALDH8A1 also participates in detoxifying aldehydes derived from lipid peroxidation and xenobiotic metabolism, contributing to cellular defense against oxidative stress. Emerging studies suggest its involvement in maintaining retinoid signaling pathways and redox balance.
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