AKAP3 antibody
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935106861
info@markelab.com
name
AKAP3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00255
tested applications
ELISA, WB, IHC
Description
May function as a regulator of both motility-and head-associated functions such as capacitation and the acrosome reaction.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A kinase(PRKA) anchor protein 3 (AKAP3) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 0B8 |
| Observed MW | 100 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O75969 |
| Gene ID | 10566 |
| Alias | Fibrousheathin I,AKAP-3 |
| Background | Antibody anti-AKAP3 |
| Status | RUO |
| Note | Mol. Weight 100 kDa |
Descripción
AKAP3 is a sperm-specific scaffold protein essential for sperm motility and capacitation. It is highly enriched in the fibrous sheath of the sperm flagellum, where it anchors PKA and other signaling molecules to regulate flagellar function and cAMP signaling. AKAP3 interacts with cAMP-binding proteins, ensuring precise localization of PKA to facilitate phosphorylation events that drive sperm motility and hyperactivation. It is also involved in sperm capacitation, where cAMP signaling leads to biochemical and structural changes necessary for fertilization. AKAP3 mutations or deficiencies impair sperm motility, leading to asthenozoospermia and infertility. Its role in organizing energy production by anchoring mitochondrial proteins highlights its importance in maintaining ATP supply for sperm movement. AKAP3 is also studied as a potential biomarker for male infertility due to its exclusive expression in sperm cells.
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