AGPAT1 antibody
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Name
AGPAT1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00215
Tested Applications
ELISA, IHC, IP
Description
Converts lysophosphatidic acid(LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | 1-acylglycerol-3-phosphate O-acyltransferase 1(lysophosphatidic acid acyltransferase, alpha) (AGPAT1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1:20-1:200; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q99943 |
| Gene ID | 10554 |
| Alias | 1-AGPAT1,G15,LPAAT-alpha |
| Background | Antibody anti-AGPAT1 |
| Status | RUO |
| Note | Mol. Weight 32 kDa |
Background
AGPAT1 is a key enzyme in the phospholipid biosynthesis pathway, catalyzing the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA) by acylating the sn-2 position of LPA. Structurally, AGPAT1 is an integral membrane protein localized to the endoplasmic reticulum (ER), where it participates in the synthesis of phospholipids and triglycerides. It plays an essential role in cell membrane formation, lipid signaling, and energy storage. AGPAT1 is ubiquitously expressed and is critical for maintaining cellular lipid homeostasis. Dysregulation of AGPAT1 is associated with metabolic disorders and diseases linked to impaired phospholipid metabolism, such as insulin resistance and lipodystrophy.
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