anti- ADAMTSL4 antibody

Background

ADAMTSL4 is a non-enzymatic member of the ADAMTS-like protein family, characterized by TSRs and cysteine-rich domains. It plays a significant role in fibrillin microfibril organization and contributes to the structural integrity of the ECM. Mutations in the ADAMTSL4 gene are associated with ectopia lentis, a disorder involving lens dislocation in the eye, and other connective tissue abnormalities. ADAMTSL4 does not exhibit catalytic activity but regulates fibrillin microfibril assembly and modulates TGF-β signaling. It is widely expressed in ocular tissues, connective tissues, and the cardiovascular system, underscoring its role in ECM organization and developmental processes.