ADAMTSL4 antibody
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935106861
info@markelab.com
name
ADAMTSL4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00147
tested applications
ELISA, WB, IHC, IP
Description
Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAMTS-like 4 (ADAMTSL4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:50-1:200; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65-70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6UY14 |
| Gene ID | 54507 |
| Alias | Thrombospondin repeat-containing protein 1,ADAMTSL-4 |
| Background | Antibody anti-ADAMTSL4 |
| Status | RUO |
| Note | Mol. Weight 65-70 kDa |
Descripción
ADAMTSL4 is a non-enzymatic member of the ADAMTS-like protein family, characterized by TSRs and cysteine-rich domains. It plays a significant role in fibrillin microfibril organization and contributes to the structural integrity of the ECM. Mutations in the ADAMTSL4 gene are associated with ectopia lentis, a disorder involving lens dislocation in the eye, and other connective tissue abnormalities. ADAMTSL4 does not exhibit catalytic activity but regulates fibrillin microfibril assembly and modulates TGF-β signaling. It is widely expressed in ocular tissues, connective tissues, and the cardiovascular system, underscoring its role in ECM organization and developmental processes.
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