ADAMTS-Like Protein 4 (ADAMTSL4) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
ADAMTS-Like Protein 4 (ADAMTSL4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx003622
tested applications
WB
Description
ADAMTSL4 Antibody is a Rabbit Polyclonal antibody against ADAMTSL4. This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAMTS-Like Protein 4 (ADAMTSL4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6UY14 |
| Gene ID | 54507 |
| NCBI Accession | NP_061905.2 |
| Alias | Thrombospondin repeat-containing protein 1,ADAMTSL-4 |
| Background | Antibody anti-ADAMTSL4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADAMTSL4 is a non-enzymatic member of the ADAMTS-like protein family, characterized by TSRs and cysteine-rich domains. It plays a significant role in fibrillin microfibril organization and contributes to the structural integrity of the ECM. Mutations in the ADAMTSL4 gene are associated with ectopia lentis, a disorder involving lens dislocation in the eye, and other connective tissue abnormalities. ADAMTSL4 does not exhibit catalytic activity but regulates fibrillin microfibril assembly and modulates TGF-β signaling. It is widely expressed in ocular tissues, connective tissues, and the cardiovascular system, underscoring its role in ECM organization and developmental processes.
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