ADAMTS-Like Protein 4 (ADAMTSL4) Antibody
377€ (100 µg)
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Name
ADAMTS-Like Protein 4 (ADAMTSL4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx230147
Tested Applications
ELISA, WB, IHC, IP
Description
ADAMTSL4 Antibody is a Rabbit Polyclonal against ADAMTSL4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ADAMTS-Like Protein 4 (ADAMTSL4) Immunogen: ADAMTS-like 4 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/50 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 65-70 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6UY14 |
| Gene ID | 54507 |
| OMIM | 225100 |
| Alias | Thrombospondin repeat-containing protein 1,ADAMTSL-4 |
| Background | Antibody anti-ADAMTSL4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADAMTSL4 is a non-enzymatic member of the ADAMTS-like protein family, characterized by TSRs and cysteine-rich domains. It plays a significant role in fibrillin microfibril organization and contributes to the structural integrity of the ECM. Mutations in the ADAMTSL4 gene are associated with ectopia lentis, a disorder involving lens dislocation in the eye, and other connective tissue abnormalities. ADAMTSL4 does not exhibit catalytic activity but regulates fibrillin microfibril assembly and modulates TGF-β signaling. It is widely expressed in ocular tissues, connective tissues, and the cardiovascular system, underscoring its role in ECM organization and developmental processes.
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