ACTN4 antibody

Este producto es parte de ACTN - Actinin Alpha
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935106861
info@markelab.com
name
ACTN4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00123
tested applications
ELISA, WB, IHC, IF, IP, FC

Description

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein(Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation(PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions(By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA(PubMed:22351778).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
actinin, alpha 4 (ACTN4)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
105 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF, IP, FC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
O43707
Gene ID
81
Alias
ACTN4,ACTININ-4,FSGS,FSGS1
Background
Antibody anti-ACTN4
Status
RUO
Note
Mol. Weight 105 kDa

Descripción

ACTN4 encodes alpha-actinin-4, a non-muscle isoform of the actinin family that plays a critical role in cellular motility, adhesion, and signal transduction. It is widely expressed in various tissues, where it crosslinks actin filaments and interacts with focal adhesion proteins to regulate cytoskeletal organization and mechanotransduction. ACTN4 is particularly important in podocytes of the kidney, where it contributes to the maintenance of glomerular filtration barrier integrity. Mutations in ACTN4 are associated with focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria and progressive renal failure. In addition to its structural role, ACTN4 is implicated in cancer metastasis and cell invasion, reflecting its involvement in dynamic cellular processes. Its diverse functions in cytoskeletal dynamics and signal regulation highlight its importance in cellular stability and adaptability.

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