ACTA1 antibody

Este producto es parte de ACTA1 - Actin alpha 1 skeletal muscle
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935106861
info@markelab.com
name
ACTA1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10793
tested applications
ELISA, WB, IHC, IF

Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. The ACTA1 gene encodes skeletal muscle alpha-actin, the principal actin isoform in adult skeletal muscle, which interacts with a variety of proteins to produce the force for muscle contraction. There is only the N-termninal 8 amino acids difference among the actin family members. This antibody is specific to the ACTA1. It does not cross-react with other actin isoforms.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
actin, alpha 1, skeletal muscle (ACTA1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
42 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P68133
Gene ID
58
Alias
ACTA,ASMA,CFTD,CFTD1,CFTDM,CMYP2A,CMYP2B
Background
Antibody anti-ACTA1
Status
RUO
Note
Mol. Weight 42 kDa

Descripción

ACTA1 encodes for actin alpha 1, a protein that is a key component of the thin filaments in skeletal muscle. ACTA1 is a protein that plays a crucial role in muscle formation and function. Its expression is induced by various stimuli and conditions that promote muscle development. In response to these stimuli, committed cells such as satellite cells undergo fusion to form myotubes, which eventually mature into muscle fibers. The expression of skeletal alpha actin is not only a hallmark of muscle formation but also serves as a trigger for the expression of other "myogenic genes." These genes are essential for the intricate process of muscle development and include factors involved in myoblast differentiation, fusion, and maturation. Therefore, the expression of ACTA1 is pivotal in orchestrating the molecular events necessary for the formation and maintenance of skeletal muscle tissue. The regulation of ACTA1 expression is tightly controlled and is influenced by various signaling pathways and transcription factors involved in muscle development and regeneration. Dysregulation of ACTA1 expression or mutations in the ACTA1 gene can lead to muscle disorders and myopathies, highlighting the critical role of skeletal alpha actin in muscle biology and physiology.

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Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. The ACTA1 gene encodes skeletal muscle alpha-actin, the principal actin isoform in adult skeletal muscle, which interacts with a variety of proteins to produce the force for muscle contraction. There is only the N-termninal 8 amino acids difference among the actin family members. This antibody is specific to the ACTA1. It does not cross-react with other actin isoforms.

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