ACSL3 antibody
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Name
ACSL3 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00107
Tested Applications
ELISA, WB, IF
Description
Acyl-CoA synthetases(ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis(By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates(By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL(very low density lipoproteins).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | acyl-CoA synthetase long-chain family member 3 (ACSL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 80 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95573 |
| Gene ID | 2181 |
| Alias | ACSL3, LACS3, ACS3, FACL3, LACS 3 |
| Background | Antibody anti-ACSL3 |
| Status | RUO |
| Note | Mol. Weight 80 kDa |
Background
ACSL3 is a long-chain acyl-CoA synthetase that catalyzes the activation of long-chain fatty acids by converting them into acyl-CoA derivatives, facilitating their utilization in β-oxidation, lipid storage, and biosynthesis pathways. ACSL3 is widely expressed in various tissues, with a notable presence in the brain, lungs, and adipose tissue, where it plays a pivotal role in maintaining lipid homeostasis and energy production. It is particularly important in lipid droplet formation, regulating the storage of triglycerides and phospholipids. Additionally, ACSL3 is involved in modulating lipid signaling molecules, such as arachidonic acid, which influence inflammatory and cellular processes. Dysregulation of ACSL3 has been associated with metabolic disorders, cancer, and neurodegenerative diseases, highlighting its role in both energy metabolism and cellular signaling. Its activity ensures the proper distribution and use of fatty acids, making it essential for lipid-mediated cellular functions.
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