Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3) Antibody
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Description
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95573 |
| Alias | ACS3,FACL3,LACS 3,LACS3 |
| Background | Antibody anti-ACSL3 |
| Status | RUO |
Descripción
ACSL3 is a long-chain acyl-CoA synthetase that catalyzes the activation of long-chain fatty acids by converting them into acyl-CoA derivatives, facilitating their utilization in β-oxidation, lipid storage, and biosynthesis pathways. ACSL3 is widely expressed in various tissues, with a notable presence in the brain, lungs, and adipose tissue, where it plays a pivotal role in maintaining lipid homeostasis and energy production. It is particularly important in lipid droplet formation, regulating the storage of triglycerides and phospholipids. Additionally, ACSL3 is involved in modulating lipid signaling molecules, such as arachidonic acid, which influence inflammatory and cellular processes. Dysregulation of ACSL3 has been associated with metabolic disorders, cancer, and neurodegenerative diseases, highlighting its role in both energy metabolism and cellular signaling. Its activity ensures the proper distribution and use of fatty acids, making it essential for lipid-mediated cellular functions.
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Acyl-CoA synthetases(ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis(By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates(By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL(very low density lipoproteins).
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Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3) Antibody
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
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