Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3) Antibody

Background

ACSL3 is a long-chain acyl-CoA synthetase that catalyzes the activation of long-chain fatty acids by converting them into acyl-CoA derivatives, facilitating their utilization in β-oxidation, lipid storage, and biosynthesis pathways. ACSL3 is widely expressed in various tissues, with a notable presence in the brain, lungs, and adipose tissue, where it plays a pivotal role in maintaining lipid homeostasis and energy production. It is particularly important in lipid droplet formation, regulating the storage of triglycerides and phospholipids. Additionally, ACSL3 is involved in modulating lipid signaling molecules, such as arachidonic acid, which influence inflammatory and cellular processes. Dysregulation of ACSL3 has been associated with metabolic disorders, cancer, and neurodegenerative diseases, highlighting its role in both energy metabolism and cellular signaling. Its activity ensures the proper distribution and use of fatty acids, making it essential for lipid-mediated cellular functions.