ACAP3 antibody
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935106861
info@markelab.com
name
ACAP3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00071
tested applications
ELISA, WB
Description
GTPase-activating protein for the ADP ribosylation factor family.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 (ACAP3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000; IF: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 92 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96P50 |
| Gene ID | 116983 |
| Alias | CENTB5,Centaurin beta 5 |
| Background | Antibody anti-ACAP3 |
| Status | RUO |
| Note | Mol. Weight 92 kDa |
Descripción
ACAP3 functions as a GTPase-activating protein for Arf6, a regulator of membrane trafficking and cytoskeletal dynamics. It contains a PH domain, ankyrin repeats, and coiled-coil motifs, facilitating its association with phosphoinositides and Arf proteins. ACAP3 regulates endocytic recycling and membrane ruffling, crucial for migration, polarity, and adhesion. Highly expressed in neurons and epithelial cells, it contributes to dendritic spine formation, synaptic plasticity, and epithelial remodeling. Dysregulation of ACAP3 has been linked to impaired neuronal development and cancer metastasis, highlighting its role in membrane dynamics and signaling critical for cellular function and adaptation.
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