ACADSB antibody
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935106861
info@markelab.com
name
ACADSB antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00067
tested applications
ELISA, WB, IHC
Description
Has greatest activity toward short branched chain acyl-CoA derivative such as(s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-Coenzyme A dehydrogenase, short/branched chain (ACADSB) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 47 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P45954 |
| Gene ID | 36 |
| Alias | 2-MEBCAD,ACAD7,SBCAD |
| Background | Antibody anti-ACADSB |
| Status | RUO |
| Note | Mol. Weight 47 kDa |
Descripción
The ACADSB gene encodes the enzyme short/branched chain specific acyl-CoA dehydrogenase (SBCAD), which belongs to the acyl-CoA dehydrogenase family. This enzyme is involved in catalyzing the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branched-chain amino acids. ACADSB deficiency can lead to short/branched-chain acyl-CoA dehydrogenase deficiency. The enzyme exhibits substrate specificity towards short branched-chain acyl-CoA derivatives, particularly (S)-2-methylbutyryl-CoA, although it also reacts with other 2-methyl branched chain substrates and short straight chain acyl-CoAs. The encoded protein is initially produced as a mitochondrial precursor, which undergoes cleavage upon import into the mitochondria, resulting in a mature peptide of approximately 43.7 kDa.
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