ABCB10 antibody
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935106861
info@markelab.com
name
ABCB10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00030
tested applications
ELISA, WB, IP
Description
May mediate critical mitochondrial transport functions related to heme biosynthesis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-binding cassette, sub-family B(MDR/TAP), member 10 (ABCB10) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IP: 1:200-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 79 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NRK6 |
| Gene ID | 23456 |
| Alias | M-ABC2,MTABC2,EST20237 |
| Background | Antibody anti-ABCB10 |
| Status | RUO |
| Note | Mol. Weight 79 kDa |
Descripción
ABCB10, also known as mitochondrial ABC transporter-2, is primarily localized in the inner mitochondrial membrane and plays a critical role in mitochondrial function and heme biosynthesis. It is involved in transporting substrates required for heme production, a vital component of hemoglobin and cytochromes. ABCB10 works in coordination with other mitochondrial transporters, such as ABCB7, to ensure proper iron-sulfur cluster biogenesis and cellular redox balance. It is highly expressed in tissues with high metabolic and oxygen demands, such as the liver, heart, and erythroid cells. Dysregulation of ABCB10 has been linked to mitochondrial dysfunction and oxidative stress, contributing to conditions such as anemia and cardiovascular diseases. Its role in maintaining mitochondrial health highlights its importance in cellular energy metabolism.
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