Annexin A4 (ANXA4) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-ANXA4
proveedor
Abbexareference
abx004799Tested Applications
ELISA, WBreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
ANXA4 Antibody is a Rabbit Polyclonal antibody against ANXA4. Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.
Background
ANXA4 is a calcium-dependent phospholipid-binding protein that participates in membrane repair, ion channel regulation, and signal transduction. It is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract, kidneys, and lungs, where it regulates cellular processes such as endocytosis and exocytosis. ANXA4 plays a role in calcium signaling, contributing to ion transport and epithelial barrier function. Overexpression of ANXA4 has been observed in cancers such as ovarian, breast, and gastric cancers, where it promotes tumor cell migration and chemoresistance. Its role in maintaining membrane integrity and ion balance highlights its importance in epithelial homeostasis and tumor progression.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Annexin A4 (ANXA4)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ANXA4
dry ice
No
availability
Shipped within 5-10 working days.
alias
ANXA4,ANX4,Annexin IV,Annexin-4
uniprot id
NCBI accession
NP_001144.1
note
Concentration: > 0.2 mg/ml -
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