Ankyrin Repeat Domain-Containing Protein 52 (ANR52) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Ankyrin Repeat Domain-Containing Protein 52 (ANR52) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025920
tested applications
ELISA, WB, FCM
Description
Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ankyrin Repeat Domain-Containing Protein 52 (ANR52) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NB46 |
| Alias | ANKRD52,ANKRD33,ANR52 |
| Background | Antibody anti-ANKRD52 |
| Status | RUO |
Descripción
ANKRD52 is a protein characterized by multiple ankyrin repeat domains that facilitate protein-protein interactions and regulatory functions. ANKRD52 serves as a regulatory subunit within protein phosphatase 6 (PP6) complexes, which are critical for modulating phosphorylation in cellular signaling pathways. It plays a role in controlling cell cycle progression, DNA damage repair, and cellular responses to genotoxic stress. ANKRD52 is particularly important in maintaining genomic integrity and regulating checkpoint signaling during DNA replication and repair. Dysregulation of ANKRD52 has been linked to tumorigenesis and impaired cell growth, where disruption of phosphatase activity can result in abnormal cell signaling and genomic instability. Its involvement in phosphatase regulation highlights its critical role in maintaining cellular homeostasis.
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