Ankyrin Repeat Domain-Containing Protein 52 (ANKRD52) Antibody

Background

ANKRD52 is a protein characterized by multiple ankyrin repeat domains that facilitate protein-protein interactions and regulatory functions. ANKRD52 serves as a regulatory subunit within protein phosphatase 6 (PP6) complexes, which are critical for modulating phosphorylation in cellular signaling pathways. It plays a role in controlling cell cycle progression, DNA damage repair, and cellular responses to genotoxic stress. ANKRD52 is particularly important in maintaining genomic integrity and regulating checkpoint signaling during DNA replication and repair. Dysregulation of ANKRD52 has been linked to tumorigenesis and impaired cell growth, where disruption of phosphatase activity can result in abnormal cell signaling and genomic instability. Its involvement in phosphatase regulation highlights its critical role in maintaining cellular homeostasis.