Ankyrin Repeat Domain-Containing Protein 16 (ANKRD16) Antibody

Este producto es parte de ANKRD - Ankyrin repeat domain
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Ankyrin Repeat Domain-Containing Protein 16 (ANKRD16) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037733
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the ANKRD16 protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Ankyrin Repeat Domain-Containing Protein 16 (ANKRD16)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
ANKRD16
Background
Antibody anti-ANKRD16
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

ANKRD16 is a protein containing multiple ankyrin repeat domains, which mediate protein-protein interactions and play key roles in cellular processes such as transcriptional regulation and protein stability. ANKRD16 has been identified as a tRNA splicing factor that interacts with components of the tRNA splicing machinery to ensure proper RNA maturation and protein synthesis. Loss of ANKRD16 function disrupts tRNA homeostasis, leading to the accumulation of defective RNA species and cellular stress. ANKRD16 is also involved in maintaining proteostasis and preventing the accumulation of misfolded proteins, which has been linked to neurodegenerative disorders. Recent studies suggest its role as a neuroprotective factor due to its ability to regulate tRNA quality control pathways, and mutations or dysregulation of ANKRD16 have been associated with neurodevelopmental diseases and certain cancers.
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