Angiotensin I Converting Enzyme (ACE) Antibody
292.5€ (80 µl)
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name
Angiotensin I Converting Enzyme (ACE) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033685
tested applications
ELISA, WB
Description
ACE is an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes the somatic form and the testicular form that are equally active.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiotensin I Converting Enzyme (ACE) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P12821 |
| Alias | ACE1,CD143,DCP,DCP1,ICH,MVCD3 |
| Background | Antibody anti-ACE |
| Status | RUO |
Descripción
Angiotensin converting enzyme (ACE) is a pivotal enzyme in the Renin-Angiotensin-Aldosterone System (RAAS), a key regulator of blood pressure and fluid balance in the body. ACE plays a crucial role in converting angiotensin I to angiotensin II, a potent vasoconstrictor, thereby increasing blood pressure. ACE inhibitors are commonly prescribed medications that block this conversion, leading to vasodilation and reduced blood pressure. Apart from its role in blood pressure regulation, ACE also has functions in the metabolism of other peptides, including bradykinin. Dysregulation of ACE activity is associated with various cardiovascular diseases, such as hypertension, heart failure, and myocardial infarction. ACE inhibitors are widely used in the management of hypertension, heart failure, and certain kidney diseases. ACE gene polymorphisms have been linked to differences in individual responses to ACE inhibitors and susceptibility to cardiovascular diseases. Understanding the role of ACE has led to the development of novel therapeutic strategies targeting the RAAS for the treatment of cardiovascular disorders.
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